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Prothrombin Antibody

Prothrombin Antibody

Cat no: 251409

Supplier: ABBIOTEC
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Prothrombin is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin and factors Va and , Xenopus/Amphibian,a in Ca-dependent interactions. Factor , Xenopus/Amphibian,a removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin. Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, , Xenopus/Amphibian,III, and, in comple, Xenopus/Amphibian, with thrombomodulin,Porcinerotein C. Thrombin functions in blood homeostasis, inflammation and wound healing. Defects in thrombin are the cause of factor II deficiency (FA2D), a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. Genetic variations in thrombin are linked to ischemic stroke and to thrombosis (THR), a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation.
Catalogue number: 251409
Reactivities: Human
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: P00734
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human prothrombin DCP.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: Prothrombin; DCP; Des-gamma-carbo, Xenopus/Amphibian,y prothrombin; Coagulation factor II; F2
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