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ProTx-I

Cat no: RTP-200

ProTx-I

ProTx-I. Potent Blocker of NavпїЅand Cav3 Channels.

Native ProTx-I has been isolated from the venom of the tarantula Thrixopelma pruriens. It was purified on the basis of its ability to reversibly inhibit the tetrodotoxin (TTX)-resistant Na channel Nav1.8. Structurally, ProTx-I is shown to belong to the inhibitory cystine knot (ICK) family of peptidyl toxins interacting with voltage-gated ion channels. ProTx-I was also found to be an inhibitor for TTX sensitive Nav channels such Nav1.5, Nav1.7 and Nav1.3 with IC50 values below 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of Cav 3.1 alpha(1G), (IC50~50 nM) without affecting the voltage dependence of inactivation.

Alomone Labs is pleased to offer ProTx-I, a recombinant peptide expressed in and extracted from E. coli and purified to homogeneity.

Ion Channel Modulators; Voltage - Gated Ca2+ Channel Blockers; Voltage - Gated Na+ Channel Blockers.

Prices direct from Alomone Labs Ltd.

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SPECIFICATIONS

Catalog Number

RTP-200

Size

5 x 5 micro g

Purity

>98%

Concentration

10-100 nM.

Shipping Temp

Room Temperature

Molecular Weight

3987.5 da

SUPPLIER INFO

Alomone Labs Ltd.

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