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PS48 ((2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoic Acid)

Cat no: P9120-02


Supplier: United States Biological
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An allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (kD = 10.3uM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site. It has recently been found that a combination of PS48, sodium butyrate, a histone deacetylase inhibitor and the gene Oct-4, could enhance the reprogramming efficiency of keratinocytes isolated from human skin or hair follicles over 25-fold. Molecular Weight: ~286.75 Solubility: DMSO (100mM) or EtOH (50mM) Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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