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PSAP pAb

PSAP pAb

Cat no: BS6711

Supplier: Bioworld Technology, Inc.
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The saposin family includes four structurally related activator proteins, saposin A, B, C and D, that are cleaved from the single precursor protein prosaposin. The gene encoding human prosaposin maps to chromosome 10. Prosaposin is synthesized as a protein that is posttranslationally modified to a shorter form and then further glycosylated to yield a secretory product. This form subsequently undergoes partial proteolysis to produce saposin A, B, C and D. Each saposin family member acts in conjunction with hydrolase enzymes to facilitate the brea own of glycosphingolipids within the lysosome. The saposins modify the environment of target lipids to make them accessible to the active sites of specific enzymes. Saposin A and C are involved in the hydrolysis of glucosylceramidase, and defects in saposin C are linked to Gaucher's disease. Saposin B facilitates the hydrolysis of the sulfate group from cerebroside sulfate, and defects in this protein are responsible for a form of metachromatic leukodystropy, a progressive neurodegenerative condition. Saposin D may stimulate the hydrolysis of sphingomyelin and ceramide, but its exact physiological role is not clear.
Catalogue number: BS6711
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P07602
Dilutions: WB: 1:500~1:2000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Recombinant full length Human PSAP.
Species: PSAP pAb detects endogenous levels of PSAP protein.
Molecular weight: ~ 58 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: A1 activator; Cerebroside sulfate activator; Co-beta-glucosidase; Component C; CSAct; Dispersin; GLBA; Glucosylceramidase activator; Proactivator polypeptide; Proactivator polypeptide precursor; Prosaposin (sphingolipid activator protein 1); prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy); Prosaposin; Protein A; Protein C; PSAP; SAP-1; SAP-2; SAP; SAP1; Saposin A; Saposin B; Saposin B Val; Saposin C; Saposin D; Saposin-D; Saposins; Sphingolipid activator prote
Additional info: For research use only, not for use in diagnostic procedure.

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