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PSEN1/ PS-1 (S28) pAb

PSEN1/ PS-1 (S28) pAb

Cat no: BS1298

Supplier: Bioworld Technology, Inc.
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A novel protein, designated Presenilin 1 (also designated S182) and mapping to the AD3 locus of chromosome 14q24.3, has been described. Mutations in the gene encoding Presenilin 1 have been found in families suffering from early-onset Alzheimer's disease. A highly related protein, designated Presenilin 2 (also designated STM2), shares 80% amino acid sequence identity with Presenilin 1. Presenilin 1 and Presenilin 2 have similar structures and represent novel members of the seven-pass transmembrane receptor superfamily. Point mutations in the gene encoding Presenilin 2 have been found in Volga German families who suffer from an inherited form of early-onset Alzheimer's disease. Whether these proteins function as ligand-gated ion channels or G protein-coupled receptors has yet to be resolved. ALG-3, the mouse homolog of human Presenilin 2, has been cloned from the mouse liver cDNA library.
Catalogue number: BS1298
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P49768
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids N-terminus of Human PSEN1.
Species: Presenilin 1 (S28) pAb detects endogenous levels of Presenilin 1 protein.
Molecular weight: 22, 55kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: PSEN1; AD3; FAD; PS-1; PS1; S182; Presenilin 1
Additional info: For research use only, not for use in diagnostic procedure.

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