PSEN1/ PS-1 (S28) pAb

A novel protein, designated Presenilin 1 (also designated S182) and mapping to the AD3 locus of chromosome 14q24.3, has been described. Mutations in the gene encoding Presenilin 1 have been found in families suffering from early-onset Alzheimer's disease. A highly related protein, designated Presenilin 2 (also designated STM2), shares 80% amino acid sequence identity with Presenilin 1. Presenilin 1 and Presenilin 2 have similar structures and represent novel members of the seven-pass transmembrane receptor superfamily. Point mutations in the gene encoding Presenilin 2 have been found in Volga German families who suffer from an inherited form of early-onset Alzheimer's disease. Whether these proteins function as ligand-gated ion channels or G protein-coupled receptors has yet to be resolved. ALG-3, the mouse homolog of human Presenilin 2, has been cloned from the mouse liver cDNA library.

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SPECIFICATIONS

Catalog Number

BS1298

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids N-terminus of Human PSEN1.

Species

Presenilin 1 (S28) pAb detects endogenous levels of Presenilin 1 protein.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200

Swiss Prot

P49768

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul