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Pseurotin A

Pseurotin A

Cat no: P9176-45

Supplier: United States Biological
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Pseurotin A is a fungal metabolite with an unusual hetero-spirocyclic ring system. It has been shown to have potent neuritogenic activity in PC12 phaechromocytoma cells, a useful model for adrenergic neuronal differentiation. Pseurotin A induced multipolar and branching neurites comparable to beta-NGF, an endogenous neurotrophic factor. Pseurotin A is also reported to exhibit chitinase inhibition and displays synergistic activity with azole antifungal agents. Purity: >99% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO.
Catalogue number: P9176-45
Size: 1mg
Purity: >99% by HPLC
References: 1. Novel neuritogenic activities of pseurotin A and penicillic acid. Komagata D. et al. J. Antibiot. 1996, 49, 958. 2. Synerazol, a new antifungal antibiotic. Ando O. et al. J. Antibiot. 1991, 44, 382. 3. Pseurotin, a new metabolite of Pseudeurotium ovalis Stolk having an unusual hetero-spirocyclic system. Bloch P. et al. Helv. Chim. Acta 1976, 59, 133.

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