PSMC5 pAb

The 26S proteasome is a highly ordered proteinase complex consisting of a 20S core and a 19S regulator. While the core is responsible for the proteolytic activity of the proteasome, the regulator contains several ATPase subunits which function in the ATP-dependent degradation of ubiquitinated proteins and confer substrate specificity to the 26S complex. SUG1, also known as PSMC5 (Proteasome 26S subunit ATPase 5), p45 or S8, is an ATPase subunit that is an integral part of the 26S proteasome complex. Localized to the cytoplasm and nucleus, SUG1 is part of the 19S regulator and functions in the ubiquitin/proteasome-mediated degradation of proteins (specifically receptors) found in the endoplasmic reticulum (ER). Recent studies suggest that assembly of the 26S proteasome is dependent upon phosphorylation of SUG1 by a protein kinase. In vitro, SUG1 also interacts with RXR (retinoid X receptor) and TR (thyroid hormone receptor), suggesting a possible role in transcriptional regulation

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SPECIFICATIONS

Catalog Number

BS6713

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human PSMC5.

Species

PSMC5 pAb detects endogenous levels of PSMC5 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

P62195

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 46 kDa

Alternative Names

26S protease regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; Cim3; MSUG1 protein; p45; p45/SUG; Proteasome 26S ATPase subunit 5; Proteasome 26S subunit ATPase 5; Proteasome prosome macropain 26S subunit ATPase 5; Proteasome subunit p45; PRS8; PSMC5; Rpt6; S8; SUG1; Tat binding protein homolog 10; TBP10; Thyroid hormone receptor interacting protein 1; Thyroid hormone receptor-interacting protein 1; Thyroid receptor interactor 1; TRIP1; TRIP1(SUG1);