PTEN (1B8) Antibody

Cat no: 252929

Supplier: ABBIOTEC

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Description
Additional Information

PTEN (Phosphatase and tensin homolog) is a dual-specificity protein phosphatase, dephosphorylating tyrosine-, threonine- and serine-phosphorylated proteins. PTEN has also a lipid phosphatase activity that is critical for its tumor suppression function. PTEN antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. Defects in PTEN are the cause of numerous cancers such as in Cowden disease (breast, thyroid and skin cancer predisposition), Lhermitte-Duclos disease, and head and neck squamous cell carcinoma.

Catalogue number:	252929
Reactivities:	Human, Mouse
Applications:	Flow Cytometry, Immunofluorescence
Size:	0.1 ml
Accession:	P60484, NP_000305
Antigen:	Purified recombinant fragment of PTEN e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml IgG in PBS pH7.4, 50% glycerol with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	1B8
Additional info:	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Phosphatase and tensin homolog; Mutated in multiple advanced cancers 1; MMAC1, TEP1