PTIP, NT (PAX-interacting Protein 1, PAX Transactivation Activation Domain-interacting Protein, PAXIP1, PAXIP1L, CAGF28)

Cat no: P9182-50D

Supplier: United States Biological

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PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. Tandem BRCT (BRCA1 carboxyl-terminal) domains in PTIP and in BRCA1 serve as phosphoserine or phosphothreonine specific binding modules that recognize substrates phosphorylated by the kinases ATM and ATR in response to gamma irradiation. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:64,000 Western Blot: 1-3ug/ml, HeLa cell lysates observed on ~95kDkD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	P9182-50D
Reactivities:	Human
Hosts:	Goat
Applications:	ELISA, Western Blot
Size:	100ug
Form:	Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type:	Pab
Purity:	Purified by immunoaffinity chromatography.
Additional info:	Recognizes human PTIP.

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PTIP, NT (PAX-interacting Protein 1, PAX Transactivation Activation Domain-interacting Protein, PAXIP1, PAXIP1L, CAGF28)

Cat no: P9182-50D

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