PTP-1B Antibody

Cat no: 250841

Supplier: ABBIOTEC

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Description
Additional Information

Protein-tyrosine phosphatase 1B (PTP-1B), a member of the protein tyrosine phosphatase (PTP) catalyzes the hydrolysis of the phosphate monoesters specifically in tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentation,Mouse,itotic cycle, and oncogenic transformation. PTP-1B acts as a negative regulator of insulin signaling by dephosphorylating the phosphotyrosine residues of insulin receptor kinase. PTP-1B dephosphorylates epidermal growth factor kinase as well as JAK2 and TYK2 kinases in cell growth control and cell response to interferon stimulation. PTP-1B plays an important role in CKII- and p60c-src-induced signal tranduction cascades.

Catalogue number:	250841
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P18031
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PTP-1B.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	PTP-1B; Protein-tyrosine phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTPN1; PTP1B