PTPRN2 pAb

Protein-Tyrosine Phosphatase Receptor-Type IA-2(beta) (PTP IA-2(beta)), alternately known as PTPRN2 or Phogrin, localizes in dense-core secretory vesicles of pancreas islet cells and influences insulin secretion. The PTP IA-2(beta) precursor is an autoantigen that contributes to insulin-dependent diabetes mellitus (IDDM). The autoantigenic epitopes of PTP IA-2(beta) appear within the cytoplasmic domain of this transmembrane protein. PTP IA-2(beta) is present at high levels in brain and pancreas with lower levels in trachea, prostate, stomach and spinal cord. The human PTPRN2 gene maps to chromosome 7q36. Northern blot analysis showed that PTPRN2 was expressed as 5.5- and 3.7-kb transcripts primarily in human brain and pancreas. Three alternative transcript splice variants of this gene encode distinct proteins.

Prices direct from Bioworld Technology, Inc.

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

BS5871

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 248-293 of Human PTPRN2.

Species

PTPRN2 pAb detects endogenous levels of PTPRN2 protein.

Dilutions

WB: 1:500~1:1000

Swiss Prot

Q92932

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 60, 64, 135 kDa

Alternative Names

Receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; Phogrin; KIAA0387; PTP IA-2(beta); PTPIA-2(beta); PTP-IA-2(beta); PTP-IA2(beta); PTP IA2(beta)