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PTPRN2 pAb

PTPRN2 pAb

Cat no: BS5871

Supplier: Bioworld Technology, Inc.
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Protein-Tyrosine Phosphatase Receptor-Type IA-2(beta) (PTP IA-2(beta)), alternately known as PTPRN2 or Phogrin, localizes in dense-core secretory vesicles of pancreas islet cells and influences insulin secretion. The PTP IA-2(beta) precursor is an autoantigen that contributes to insulin-dependent diabetes mellitus (IDDM). The autoantigenic epitopes of PTP IA-2(beta) appear within the cytoplasmic domain of this transmembrane protein. PTP IA-2(beta) is present at high levels in brain and pancreas with lower levels in trachea, prostate, stomach and spinal cord. The human PTPRN2 gene maps to chromosome 7q36. Northern blot analysis showed that PTPRN2 was expressed as 5.5- and 3.7-kb transcripts primarily in human brain and pancreas. Three alternative transcript splice variants of this gene encode distinct proteins.
Catalogue number: BS5871
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: Q92932
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 248-293 of Human PTPRN2.
Species: PTPRN2 pAb detects endogenous levels of PTPRN2 protein.
Molecular weight: ~ 60, 64, 135 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; Phogrin; KIAA0387; PTP IA-2(beta); PTPIA-2(beta); PTP-IA-2(beta); PTP-IA2(beta); PTP IA2(beta)
Additional info: For research use only, not for use in diagnostic procedure.

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