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PUMA (R169) Peptide

PUMA (R169) Peptide

Cat no: BS2922P

Supplier: Bioworld Technology, Inc.
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PUMA (Bcl-2 binding component 3, JFY1, PUMA/JFY1) is a mitochondrial pro-apoptotic Bcl-2 homology domain (BH3)-only protein that induces rapid apoptosis through a Bax- and mitochondria-dependent pathway. The PUMA gene encodes four proteins originating from different splice variants of the same transcript: PUMAalpha, beta, gamma and delta. Both PUMAalpha and PUMAbeta contain a BH3 domain, while PUMAgamma and PUMAdelta lack this domain. The BH3 domain is essential for binding of PUMAalpha and PUMAbeta to Bcl-2 or Bcl-xL. PUMA is an initiator of gamma -radiation apoptosis and glucocorticoid-induced apoptosis in lymphoid cells in vivo. Bcl-2 family members generally regulate apoptosis and transmit death signals to mitochondria. Members of this family include both pro- and anti-apoptotic proteins that share homologous sequences known as Bcl-2 homology domains (BH1-4). The BH3 proteins, BID, NOXA, PUMA, NBK, Bim and Bad, are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region.
Catalogue number: BS2922P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q9BXH1
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide PUMA (R169). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: BBC 3 antibody BBC3 antibody BCL 2 binding component 3 antibody BCL2 binding component 3 antibody JFY 1 antibody JFY1 antibody p53 up regulated modulator of apoptosis antibody p53 Upregulated Modulator of Apoptosis antibody PUMA alpha antibody PUMA/JFY1 antibody
Additional info: This peptide can be used with studies using BS2922 PUMA (R169) pAb.

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