PUMA (R169) Peptide

PUMA (Bcl-2 binding component 3, JFY1, PUMA/JFY1) is a mitochondrial pro-apoptotic Bcl-2 homology domain (BH3)-only protein that induces rapid apoptosis through a Bax- and mitochondria-dependent pathway. The PUMA gene encodes four proteins originating from different splice variants of the same transcript: PUMAalpha, beta, gamma and delta. Both PUMAalpha and PUMAbeta contain a BH3 domain, while PUMAgamma and PUMAdelta lack this domain. The BH3 domain is essential for binding of PUMAalpha and PUMAbeta to Bcl-2 or Bcl-xL. PUMA is an initiator of gamma -radiation apoptosis and glucocorticoid-induced apoptosis in lymphoid cells in vivo. Bcl-2 family members generally regulate apoptosis and transmit death signals to mitochondria. Members of this family include both pro- and anti-apoptotic proteins that share homologous sequences known as Bcl-2 homology domains (BH1-4). The BH3 proteins, BID, NOXA, PUMA, NBK, Bim and Bad, are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region.

Prices direct from Bioworld Technology, Inc.

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

BS2922P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide PUMA (R169). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q9BXH1

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS2922 PUMA (R169) pAb.

Alternative Names

BBC 3 antibody \nBBC3 antibody \nBCL 2 binding component 3 antibody \nBCL2 binding component 3 antibody \nJFY 1 antibody \nJFY1 antibody \np53 up regulated modulator of apoptosis antibody \np53 Upregulated Modulator of Apoptosis antibody \nPUMA alpha antibody \nPUMA/JFY1 antibody