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Purified anti-a-Adducin

Purified anti-a-Adducin

Cat no: 617001

Supplier: BioLegend
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The alpha-adducin protein is a ubiquitously expressed cytoskeletal protein that binds with high affinity to Ca2+/calmodulin and acts as a substrate for protein kinases A and C. alpha-addducin is a 80-120 kD member of the aldolase class II family and adducin subfamily. This protein has three isoforms that interact as heterodimers alpha/beta, and alpha/gamma. The molecular weights for the various isoforms are alpha=120 kD; beta=110kD; gamma=80kD. This protein has been reported to promote the assembly of the spectrin-actin network. Polymorphisms in alpha-adducin are associated with cardiovascular disease and hypertension. alpha-adducin has been reported to interact with calmodulin. When phosphorylated by Rho-kinase, alpha-adducin can regulate membrane ruffling and cell motility. The Poly6170 antibody has been shown to be useful for Western blotting of mouse and human alpha-adducin protein.
Catalogue number: 617001
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 50 microl
Clone: Poly6170
Gene: 118
Dilutions: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store frozen at -20 C.
Antigen: Recombinant (partial)
Isotype: Rabbit Polyclonal
Clonality: Polyclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: -20 C
Alternative names: ADD-1, alpha-Adducin
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