Home  >  Products  >  Purified anti-APC10
Purified anti-APC10

Purified anti-APC10

Cat no: 611501

Supplier: BioLegend
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
APC10 (anaphase-promoting complex subunit 10) is a member of the E3 enzyme family. This protein contains a Doc domain and has a molecular weight of approximately 21 kD. The APC10 protein is located at the centrosomes and mitotic spindles throughout mitosis and the kinetochores from prophase to anaphase, and at the midbody during telophase and cytokinesis. The APC10 protein is involved in substrate recognition and acts as a processivity factor. The APC10 protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC10 protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1. The Poly6115 antibody has been shown to be useful for Western blotting of the human and mouse APC10 protein.
Catalogue number: 611501
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 50 microl
Clone: Poly6115
Gene: 324
Dilutions: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store frozen at -20 C.
Antigen: Recombinant (partial), N-terminal
Isotype: Rabbit Polyclonal
Clonality: Polyclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: -20 C
Alternative names: Anaphase-promoting complex subunit 10, Doc1
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave