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Purified anti-APC8

Purified anti-APC8

Cat no: 611402

Supplier: BioLegend
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APC8 (anaphase-promoting complex subunit 8) is a member of the E3 enzyme family. This protein contains TPR repeats and has a molecular weight of approximately 68 kD. The APC8 protein is located in the nucleus during interphase and the centrosome during metaphase/anaphase. This protein is required for mitotic anaphase transition. The APC8 protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC8 protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1. APC8 is phosphorylated by cdk1-cyclinB and PLK-1. The Poly6114 antibody has been shown to be useful for Western blotting of the human and mouse APC8 protein.
Catalogue number: 611402
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 200 microl
Clone: Poly6114
Gene: 324
Dilutions: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store frozen at -20 C.
Antigen: Recombinant (partial), N-terminal
Isotype: Rabbit Polyclonal
Clonality: Polyclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: -20 C
Alternative names: Anaphase-promoting complex subunit 8, Cell division cycle protein 23 (Cdc23), Cut23
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