Purified anti-Bax

Cat no: 633701

Supplier: BioLegend

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Bax is a 21 kD pro-apoptotic protein known to regulate apoptosis. Bax is found in the cytoplasm, mitochondria, and nucleus and is highly expressed in hematopoietic stem cells, the ovary, and in the lymph node. Bax binds the anti-apoptotic protein Bcl-2 as a heterodimer or forms homodimers. The relative levels of pro-apoptotic proteins such as Bax and anti-apoptotic proteins such as Bcl-2 determines whether cell death will occur following an apoptotic stimulus. Bax accelerates the opening of mitochondrial VDAC altering membrane potential and allowing cytochrome c to pass out of the mitochondria into the cytosol to initiate downstream caspase activation. p53 can transcriptionally activate the Bax gene to induce apoptosis. Bax has been shown to be mutated in some human cancers. Clone 5B7 has been shown to be useful for western blotting and immunoprecipitation of the mouse Bax protein.This antibody does not cross-react with Bcl-2 or Bcl-XL proteins.

Catalogue number:	633701
Reactivities:	Mouse
Hosts:	Mouse
Applications:	Immunoprecipitation, Western Blot
Size:	25 microg
Clone:	5B7
Gene:	581
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. For Western blotting, suggested working dilution(s): Use 5 microg per 5 ml antibody dilution buffer for each mini-gel. For immunofluorescence microscopy: Use a dilution range of 1~4 microg/ml. It is recommended that the reagent be titrated for optimal performance for each application.>
Storage buffer:	Upon receipt, store undiluted at at 4C.
Concentration:	0.5 mg/ml
Antigen:	Amino acids: 8-16 of murine Bax protein
Isotype:	Mouse IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	BCL2 associated X protein, apoptosis regulator Bax

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Purified anti-Bax

Cat no: 633701

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