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Purified anti-Bcl-XS/L

Purified anti-Bcl-XS/L

Cat no: 633901

Supplier: BioLegend
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Bcl-X is one of the members of Bcl-2 family proteins, and exists in several isoforms generated by alternative splicing and plays a critical role in the control of apoptosis. The large isoform Bcl-XL (30KD)contains the highly conserved BH1 and BH2 amino acid domains and protects cells against apoptosis, whereas the short isoform, Bcl-XS(18KD) which deletes the conserved BH1/BH2 domain by alternative mRNA splicing, promotes apoptosisby interacting with Bcl-XL and Bcl-2.Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.Clone 2H12 has been shown to be useful for western blotting and immunoprecipitation, immunohistochemistry, and immunofluorescence of the Human, Mouse and Rat Bcl-XL and Bcl-XS proteins.
Catalogue number: 633901
Reactivities: Human, Mouse, Rat, Porcine
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 25 microg
Clone: 2H12
Gene: 598
Dilutions: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, suggested working dilution(s): Use 5 microg per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store undiluted at at 4C.
Concentration: 0.5 mg/ml
Antigen: Amino acids: 3-14 common to human and mouse Bcl-X
Isotype: Mouse IgG2a, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Apoptosis regulator Bcl-X, Bcl-2-like 1 protein
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