Purified anti-Bcl11b

Cat no: 650601

Supplier: BioLegend

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Description
Additional Information

The transcription factor Bcl11b is expressed in thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies.

Catalogue number:	650601
Reactivities:	Human
Hosts:	Rat
Applications:	Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size:	25 microg
Clone:	25B6
Gene:	64919
Dilutions:	Each lot of this antibody is quality control tested by Western blotting and immunofluorescence microscopy. Western blotting, suggested working dilution(s): Use 0.5 microg antibody per ml antibody dilution buffer for each mini-gel. For immunofluorescence microscopy: Use a dilution of 1:200. The optimal concentration should be determined by titration for each individual assay of interest.
Storage buffer:	Upon receipt, store undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Human Bcl11b
Isotype:	Rat IgG
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	B-cell CLL/lymphoma 11B (zinc finger protein), CTIP2, B-cell lymphoma/leukemia 11B