Purified anti-Blimp-1

Cat no: 648202

Supplier: BioLegend

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Description
Additional Information

Blimp-1 is a 98 Kd protein containing five Kuppel-type zinc finger domains that confer sequence specific DNA binding. It has been postulated to be a master regulator of terminal B cell differentiation. In the BCL-1 lymphoma model of differentiation from mature B cells to plasma cells, ectopic expression of Blimp-1 is sufficient to cause terminal differentiation manifested by loss of surface immunoglobulin, IgM secretion, expression of syndecan-1 and cessation of cell division. Recently, it is reported that Blimp-1 is also involved in T cell differentiation and T cell homeostasis and suppression of IL-2 production.

Catalogue number:	648202
Reactivities:	Human
Hosts:	Mouse
Applications:	ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size:	100 microg
Clone:	ROS195G
Gene:	639
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Recombinant GST-blimp-1 protein
Isotype:	Mouse IgG1
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	B lymphocyte-induced maturation protein-1, PRDM-1, BLIMP1