Purified anti-c-MAF

Cat no: 655302

Supplier: BioLegend

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c-MAF, originally identified as a homolog of the avian viral oncogen v-maf, belongs to the family of AP-1 basic leucine zipper transcription factors. It forms homodimers or heterodimers with other family members and regulates target genes through binding to the consensus Maf recognition element (MARE) sequence. c-MAF deficient helper T cells have profound defects in producing IL-4 and in differentiating into Th2 cells. Reciprocally, overexpression of c-MAF results in production of IL-4 and attenuated Th1 differentiation. These findings indicate that c-Maf is crucial for IL-4 gene expression and regulation of Th2 differentiation. In addition, studies have also shown that c-Maf is required for the differentiation of Th17 cells as well as the production of IL-10. High expression levels of c-MAF were detected in numerous multiple myeloma cell lines, suggesting that c-MAF might function as an oncogene in multiple myeloma.

Catalogue number:	655302
Reactivities:	Human
Hosts:	Mouse
Applications:	Western Blot
Size:	100 microg
Clone:	2D9A29
Gene:	4094
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	Upon receipt, store undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Partial c-MAF recombinant protein (64-158 aa)
Isotype:	Mouse IgG2b, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene. v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

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Purified anti-c-MAF

Cat no: 655302

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