Purified anti-CAP-18

Antimicrobial peptides (AMP) are effector molecules of the innate immune system with direct antimicrobioal and immunomodulatory effects. AMP are produced by epithelial and professional host defense cells such as macrophages or neutrophils. AMP directly inactivate microorganisms and, in addition, have diverse activities on various cell types. In mammals, peptides of the defensin and the cathelicidin families are found. hCAP-18 is the only cathelicidin present in humans. hCAP-18 is a 170 amino acid cathelicidin anti-microbial precursor protein that is proteolytically processed to yield the antibacterial peptide LL-37. The precursor hCAP-18 is found in the specific granules of neutrophils and is expressed in many immune and epithelial cells. Cathelicidin has an established role in host defense. In addition to their direct antimicrobial function, cathelicidin peptides are involved in the modulation of repair and tissue homeostasis, epithelial wound healing, chemoattraction of immune cells, and release of inflammatory mediators from epithelial cells. Recent studies also found that LL-37 significantly regulates endocytic capacity, modifies expression of phagocytic receptors, increases secretion of Th1-inducing cytokines of dendritic cells (DC) generated from blood monocytes, and modulates the response of monocytes and DC to toll like receptor (TLR)–ligands. Moreover LL-37 also modulates the response of neutrophils to bacterial activation.

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SPECIFICATIONS

Catalog Number

650302

Size

100 microg

Applications

FC, IF, IHC, WB

Hosts

Mouse

Reactivities

Hum

Clone

H7

Antigen

Partially purified human neutrophil membrane proteins, with epitope mapping to amino acids 115-121

Gene Id

820

Isotype

Mouse IgG1

Clonality

Monoclonal

Dilutions

Each lot of this antibody has been quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 2 microg per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store undiluted at 4C.

Alternative Names

cathelicidin antimicrobial peptide, 18 kDa cationic antimicrobial protein, CRAMP, CAP18, cathelicidin LL-37

Regulatory Status

RUO