Purified anti-Caspase-10

Cat no: 645202

Supplier: BioLegend

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Description
Additional Information

There are two types of apoptotic caspases, initiator (apical) caspases and effector (executioner) caspases. Caspase 10 is one of the initiator caspases that cleave inactive pro-forms of effector caspases, thereby activating them. Four isoforms, namely Caspase-10a,-10 b,-10c,and -10d have been identified. They derived from a single chain polypeptide proenzyme but have different mature large and small subunits by cleavage. After the death ligand-receptor binding, caspade-10 has joined the multimeric Fas/TNF receptor complex and gets cleaved. The cleaved caspase-10 further acts on other effector caspases to initiate the caspase cascade.

Catalogue number:	645202
Reactivities:	Human, Mouse
Hosts:	Rat
Applications:	Western Blot
Size:	100 microg
Clone:	25C2
Gene:	843
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 1-2 microg antibody per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	Upon receipt, store at 4C.
Concentration:	0.5 mg/ml
Antigen:	His tagged bacterial fusion protein of caspase-10 p20
Isotype:	Rat IgG2a
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Mch4