Purified anti-Caspase-11

Cat no: 647201

Supplier: BioLegend

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Description
Additional Information

Murine caspase-11 is an upstream protease of caspase-1 and interacts with the proform of caspase-1 which in turn activates IL-1 beta. Caspase-11 is not constitutively expressed in most cell types. Its expression can be upregulated by LPS, IFN-gamma, and other pro-inflammatory stimuli. NF-kappaB and STAT1 were reported to be involved in the activation. Caspase-11 knock -out mice were resistant to endotoxin shock and do not produce IL-1 after stimulation with LPS. Their production of IFN-gamma was also deficient.

Catalogue number:	647201
Reactivities:	Mouse
Hosts:	Rat
Applications:	Western Blot
Size:	25 microg
Clone:	Cas11.17D9
Gene:	201161
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): 1 to 2 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	His tagged bacterial fusion protein of p 30 of caspase 11
Isotype:	Rat IgG2a
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Casp11