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Purified anti-Caspase 9

Purified anti-Caspase 9

Cat no: 634201

Supplier: BioLegend
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Caspase-9 is a member of the peptidase family C14 that contains a CARD domain. This caspase is active as a heterotetramer and has been reported to have two isoforms. Pro-Caspase-9 has been reported to be approximately 47 kD. This caspase is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase-9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase-3 and Caspase-6. Caspase-9 is inhibited by the dominant negative isoform, Bcl-XL, c-IAP1, c-IAP2, XIAP, and Livin. This caspase becomes activated when recruited to Apaf-1/cytochrome c complex, and following cleavage by Apaf-1, granzyme B, Caspase-3, possibly Caspase-8 and Caspase-10 into large p37 and small p10 subunits. Caspase-9 interacts with BIRC7 and has been shown to cleave PARP and vimentin. The Poly6342 antibody has been shown to be useful for western blotting ofhuman Human, Mouse and rat caspase-9 (p10) and caspase-9 precursor.
Catalogue number: 634201
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 50 microl
Clone: Poly6342
Gene: 12371
Dilutions: Each lot of this antibody is quality control tested by Western blotting. Western blotting suggested working dilution(s): Use10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. DO NOT FREEZE.
Antigen: peptide mapping to an internal domain within the p10 subunit of human caspase-9
Isotype: Rabbit Polyclonal
Clonality: Polyclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Caspase-9 precursor, Casp9, ICE-like apoptotic protease 6 (ICE-LAP6), Apoptotic protease Mch-6, Apoptotic protease activating factor 3 (Apaf-3)
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