Purified anti-Cbl

Cat no: 633001

Supplier: BioLegend

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Description
Additional Information

The proto-oncogene c-Cbl was initially identified as the cellular homologue of v-Cbl oncogene that induces pre-B cell lymphomas and myeloid leukemias in mice. The Cbl family comprises three mammalian proteins, c-Cbl, Cbl-b, and Cbl-3; among these, c-Cbl and Cbl-b are expressed in hemopoietic cells, whereas Cbl-3 is expressed only in epithelial tissues. Cbl proteins can function as E3 ubiquitin (Ub) ligases, and in more recent studies Cbl has been implicated in the negative regulation of various RTKs.The poly6330 antibody has been shown to be useful for western blotting, immunoprecipitation, and immunohistochemistry of human, mouse, and rat Cbl protein.

Catalogue number:	633001
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunoprecipitation, Western Blot
Size:	125 microl
Clone:	Poly6330
Gene:	867
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. Western blotting suggested working dilution(s): Use 25 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C. DO NOT FREEZE."
Antigen:	peptide mapping to the carboxy terminal domain of human Cbl
Isotype:	Rabbit Polyclonal
Clonality:	Polyclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	E3 ubiquitin-protein ligase Cbl, Proto-oncogene c-Cbl