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Purified anti-Cytochrome b-245 heavy chain

Purified anti-Cytochrome b-245 heavy chain

Cat no: 650101

Supplier: BioLegend
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The integral membrane protein flavocytochrome b (Cyt b), a heterodimer formed by a 91-kD glycoprotein (heavy chain) and a 22-kD polypeptide (light chain), is the catalytic core of the phagocyte NADPH oxidase and generates superoxide which plays a critical role in host defense. NADPH oxidase is a central well characterized component of the innate immune response against fungal and bacterial infections. Recent research also offers new insight into a novel role for this oxidase in the coordination of the adaptive immune response. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
Catalogue number: 650101
Reactivities: Human, Mouse
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunofluorescence, Western Blot
Size: 25 microg
Clone: 54.1
Gene: 4519
Dilutions: Each lot of this antibody has been quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.5 microg per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Partially purified human neutrophil flavocytochrome b
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: CYBB, gp91phox, cytochrome b-245 beta chain, Superoxide-generating NADPH oxidase heavy chain subunit
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