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Purified anti-Cytochrome b-245 light chain

Purified anti-Cytochrome b-245 light chain

Cat no: 650002

Supplier: BioLegend
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The integral membrane protein flavocytochrome b (Cyt b), a heterodimer formed by a 91-kD glycoprotein (heavy chain) and a 22-kD polypeptide (light chain), is the catalytic core of the phagocyte NADPH oxidase and generates superoxide which plays a critical role in host defense. The p22phox gene encodes the light alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. p22phox is a prerequisite for TNF-induced but not for Toll-like-receptor-induced ROS production. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD) that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.
Catalogue number: 650002
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100 microg
Clone: 44.1
Gene: 4519
Dilutions: Each lot of this antibody has been quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 1 microg per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Partially purified human neutrophil flavocytochrome b
Isotype: Mouse IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: CYBA, cytochrome b-245 alpha polypeptide, p22phox, flavocytochrome b-558 alpha polypeptide
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