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Purified anti-Cytokeratin 18

Purified anti-Cytokeratin 18

Cat no: 617202

Supplier: BioLegend
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Keratin 18 (also know as cytokeratin 18) is a 48 kD member of the Type I intermediate filament family, that forms heterotetramers. Keratin 18 is widely expressed in normal single layer epithelial tissues (liver, pancreas) and is expressed at high levels in some tumor tissues. Keratin 18 and filament partner keratin 8 are the most common members of intermediate filament family. Mutations in keratin 18 have been linked to cryptogenic cirrhosis. This protein is induced by retinoic acid, estrogen (breast cancer cells), and the Ras-signaling pathway (Ha-Ras, activated Src, Lck, Raf). Keratin 18 can be modified by phosphorylation, glycosylation, and ubiquitination. The active heterotetramer consists of two type I and two type II keratins (type I is acidic 40-55 kD, type II is neutral to basic 56-70 kD). Keratin 18 has been shown to associate with keratin 8, Mrj (a DnaJ/HSP40 family protein), and Hsp70. The Poly6172 antibody recognizes human and mouse keratin 18 and is useful for Western blotting.
Catalogue number: 617202
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 200 microl
Clone: Poly6172
Gene: 3875
Dilutions: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store frozen at -20 C.
Antigen: Recombinant (partial), C-terminal
Isotype: Rabbit Polyclonal
Clonality: Polyclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: -20 C
Alternative names: Cytokeratin 18, Keratin type I cytoskeletal 18
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