Purified anti-GATA3

GATA3 functions as a major regulator of T helper 2 (TH2) cell differentiation in immune cells. GATA3 expression is upregulated through IL-4 receptor signaling or the Notch-mediated pathway, which results in production of IL-4, IL-5, and IL-13 cytokines, responsible for preferential differentiation of TH2-cells. GATA3 has been shown to regulate early developmental processes of T cells, such as T cell commitment, positive selection, and post-commitment CD4+ T cell survival. In the mammary gland, GATA3 plays an important role in differentiation and commitment of luminal epithelial cells. In a mouse model, exogenous expression of GATA3 in undifferentiated breast carcinoma cells induces differentiation and suppresses spreading of the tumor cells, suggesting that GATA3 is involved in preventing malignancy of breast cancer. GATA3 has been reported to be essential in development of a variety of normal tissues. Defect in GATA3 results in hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR syndrome).

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SPECIFICATIONS

Catalog Number

653801

Size

25 microg

Applications

IF, WB

Hosts

Mouse

Reactivities

Hum, Mouse

Clone

16E10A23

Antigen

Partial human GATA3 recombinant protein (1-258 aa).

Gene Id

2625, 14462

Isotype

Mouse IgG2b, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.1-0.5 microg/ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store undiluted at 4C.

Alternative Names

GATA-binding factor 3, trans-acting T-cell-specific transcription factor GATA-3

Regulatory Status

RUO