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Purified anti-GATA3

Purified anti-GATA3

Cat no: 653802

Supplier: BioLegend
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GATA3 functions as a major regulator of T helper 2 (TH2) cell differentiation in immune cells. GATA3 expression is upregulated through IL-4 receptor signaling or the Notch-mediated pathway, which results in production of IL-4, IL-5, and IL-13 cytokines, responsible for preferential differentiation of TH2-cells. GATA3 has been shown to regulate early developmental processes of T cells, such as T cell commitment, positive selection, and post-commitment CD4+ T cell survival. In the mammary gland, GATA3 plays an important role in differentiation and commitment of luminal epithelial cells. In a mouse model, exogenous expression of GATA3 in undifferentiated breast carcinoma cells induces differentiation and suppresses spreading of the tumor cells, suggesting that GATA3 is involved in preventing malignancy of breast cancer. GATA3 has been reported to be essential in development of a variety of normal tissues. Defect in GATA3 results in hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR syndrome).
Catalogue number: 653802
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Immunofluorescence, Western Blot
Size: 100 microg
Clone: 16E10A23
Gene: 2625, 14462
Dilutions: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.1-0.5 microg/ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Partial human GATA3 recombinant protein (1-258 aa).
Isotype: Mouse IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: GATA-binding factor 3, trans-acting T-cell-specific transcription factor GATA-3
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