Purified anti-human CD170 (Siglec-5)

Cat no: 352001

Supplier: BioLegend

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Description
Additional Information

CD170, also known as Siglec-5, is a single pass transmembrane protein member of the immunoglobulin superfamily. On the cell surface, CD170 forms a 140 kD dimer. The cytoplasmic domain of Siglec-5 contains 2 ITIM motifs that recruit the tyrosine-phosphatases SHP-1 and SHP-2 after tyrosine-phosphorylation, which in turn results in the inhibition of cell signaling. Siglec-5 is expressed by granulocytes, monocytes/macrophages, subsets of lymphocytes, and a subset of activated dendritic cells. Siglec-5 binds alpha2,3- and alpha2,6-linked sialic acid as well as glycophorin A, and is involved in cell adhesion.

Catalogue number:	352001
Reactivities:	Human
Hosts:	Mouse
Applications:	ELISA, Flow Cytometry
Size:	25 microg
Clone:	1A5
Gene:	8778
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Extracellular region of Siglec-5
Isotype:	Mouse IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	OBBP2, CD33L2, OB-BP2, Siglec-5