Purified anti-human CD195 (CCR5) (cytoplasmic domain)

Cat no: 321702

Supplier: BioLegend

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Description
Additional Information

CD195, also known as CCR5, is a 45 kD G protein-coupled seven transmembrane CC-chemokine receptor. It binds to MIP-1alpha, MIP-1beta, and RANTES and is expressed on a subset of T cells and monocytes. CD195 mediates an intracellular signal thought to induce cell differentiation and proliferation. CCR5 has also been shown to act as a co-receptor for R5 HIV-1 cell entry; modification of CCR5 by sulfation contributes to the efficiency of HIV-1 entry. The R-C10 monoclonal antibody binds to nonphosphorylated serine 337 corresponding to 22 c-terminal amino acid residues of human CCR5 and is useful for flow cytometric analysis, immunoblotting, and ELISA assay of CCR5 expression.

Catalogue number:	321702
Reactivities:	Human
Hosts:	Mouse
Applications:	Immunoprecipitation, Western Blot
Size:	100 microg
Clone:	R-C10
Gene:	1234
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 1-2microg antibody per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Peptide (CEAPERASSVYTRSTGEQISVGL) of CCR5
Isotype:	Mouse IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	CCR5, C-C chemokine receptor type 5, HIV-1 fusion co-receptor