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Purified anti-human CD254 (TRANCE, RANKL)

Purified anti-human CD254 (TRANCE, RANKL)

Cat no: 347501

Supplier: BioLegend
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Human RANKL (receptor activator of NF-kB ligand), also known as TRANCE (TNF-related activation-induced cytokine receptor) and OPGL (Osteoprotegerin ligand), and CD254, is a type II transmembrane protein in theTNF superfamily. It has two forms - a membrane-anchored protein and a secreted protein. Its extracellular domain is related to TRAIL, FasL, and TNF. TRANCE is expressed on osteoclasts and activated T cells. It has been implicated in the regulation of T cell and dendritic cell interactions. RANKL plays an important role in osteoclast differentiation and bone resorption. TRANCE activates JNK and NF-kappaB and induces the expression of IL-1, IL-6, IL-12, and IL-15 in dendritic cells.
Catalogue number: 347501
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry
Size: 25 microg
Clone: MIH24
Gene: 8600
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.5 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: RANKL-transfected L cells
Isotype: Mouse IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: TNF-related activation-induced cytokine receptor (TRANCE), CD254, RANK-L, OPGL, SOFA, TNFSF-11
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