Purified anti-human CD255 (TWEAK)

Cat no: 308402

Supplier: BioLegend

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Description
Additional Information

TNF-like weak inducer of apoptosis (TWEAK) is a type II transmembrane TNF superfamily member with strong homology to TNF in its extracellular portion, though less potent in inducing apoptosis. It has been clustered as CD255. TWEAK transcript is expressed broadly in many adult and fetal tissues; however, the staining of human peripheral blood mononuclear cells with TWEAK-specific antibodies shows a more restricted pattern. TWEAK is expressed as membrane-bound and secreted forms. Interaction of TWEAK with its receptors (DR3, Fn14) promotes secretion of IL-8, activation of NF-kappaB, proliferation of endothelial cells, and apoptosis in a number of human cell lines. The CARL-2 antibody can neutralize the bioactivity of natural or recombinant TWEAK.

Catalogue number:	308402
Reactivities:	Human
Hosts:	Mouse
Applications:	Flow Cytometry
Size:	100 microg
Clone:	CARL-2
Gene:	8472
Dilutions:	Each lot of this antibody is quality control tested by sandwich ELISA. For ELISA capture applications, a concentration range of 1-4 microg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	hTWEAK/2PK-3 transfectant cells
Isotype:	Mouse IgM, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	TNF-like weak inducer of apoptosis, Apo-3 ligand, DR3-L, TNFSF-12