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Purified anti-human CD257 (BAFF, BLYS)

Purified anti-human CD257 (BAFF, BLYS)

Cat no: 318602

Supplier: BioLegend
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The T7-241 antibody recognizes human BAFF also known as B cell activating factor, tumor necrosis factor ligand superfamily 13B, B lymphocyte stimulator (BLYS), TNF and APOL-related leukocyte expressed ligand 1 (TALL1), and TNF homolog that activates apoptosis, NF-kappaB, and JNK (THANK). BAFF is a type II transmembrane protein, and a member of the tumor necrosis factor ligand superfamily. BAFF can be proteolytically cleaved to form a soluble protein. BAFF, like other TNF ligand family members, forms homotrimers. The predicted molecular weight of a BAFF monomer is approximately 31 kD. BAFF is expressed on peripheral blood B and T lymphocytes, monocytes, macrophages, and dendritic cells and is upregulated by IFN-gamma and downregulated by PMA/ionomycin treatment. The T7-241 antibody has been shown to be useful for flow cytometry and ELISA. BAFF stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors; BAFF prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3). The T7-241 antibody has been shown to be useful for flow cytometry and ELISA.
Catalogue number: 318602
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry
Size: 100 microg
Clone: T7-241
Gene: 10673
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?2.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: recombinant human BAFF(TL7) protein
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: BAFF, BLYS, TL7, TALL1, TNFSF13b
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