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Purified anti-human CD281 (TLR1)

Purified anti-human CD281 (TLR1)

Cat no: 317501

Supplier: BioLegend
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Toll-like receptors (TLRs) are type I transmembrane signaling receptors characterized by containing leucine-rich repeats (LRR) extracellular domain and IL-1 receptor like intracellular domain. TLRs are responsible for recognizing pathogen-associated molecule patterns (PAMPs). They are primary sensors of both innate and adaptive immune systems. To date a total of 12 TLRs have been indentified. Toll-like receptor 1 (TLR1), known as CD281, is expressed on monocytes/macrophages, dendritic cells, and granulocytes and some lymphocytes at low levels. By association with TLR2, TLR1 is a coreceptor involved in the response to diverse set of pathogens, such as triacylated lipopeptidess (but not diacylated lipopeptides), peptidoglycans, lipoteichoic acid. The GD2.F4 antibody can be used for flow cytometry and for neutralization of TLR1.
Catalogue number: 317501
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 25 microg
Clone: GD2.F4
Gene: 7096
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 2.0 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Toll like Receptor 1, TLR-1, TLR1
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