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Purified anti-human CD354 (TREM-1)

Purified anti-human CD354 (TREM-1)

Cat no: 316102

Supplier: BioLegend
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TREM-1 is a 30 kD glycoprotein also known as triggering receptor expressed on myeloid cells 1, and triggering receptor expressed on monocytes 1. It is a Type I membrane protein that contains an immunoglobulin-like V-type domain. Alternatively spliced protein variant may be secreted. TREM-1 is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes); TREM-1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM-1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. TREM-1 is thought to amplify inflammatory responses to fungal and bacterial infections and potentiate septic shock. This antibody has been shown to be useful for Western blotting, flow cytometric staining, and ELISA pairing with biotinylated TREM-26 antibody (Cat. No. 314904) as a detection antibody.
Catalogue number: 316102
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Western Blot
Size: 100 microg
Clone: TREM-37
Gene: 54210
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.5 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Recombinant human TREM-1
Isotype: Mouse IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Triggering receptor expressed on myeloid cells 1, triggering receptor expressed on monocytes 1
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