Purified anti-human CD49b

Cat no: 314304

Supplier: BioLegend

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Description
Additional Information

CD49b is a 170 kD transmembrane protein, also known as alpha2 integrin, VLA-2 alpha chain, Integrin alpha2 or GPIa. It associates with CD29 (beta1 integrin) to form VLA-2, a collagen and alminin receptor on many cell types including monocytes, platelets, activated T cells, megakaryocytes, neuronal cells, epithelial cells, and osteoclasts. CD49b has been reported to interact with F-actin and matrix metalloproteinase 1. CD49b is a platelet alloantigen and has been associated with neonatal alloimmune thrombocytopenia. Deficiencies in this protein have been associated with hemorrhagic disorders.

Catalogue number:	314304
Reactivities:	Human
Hosts:	Mouse
Applications:	Flow Cytometry, Immunohistochemistry
Size:	100 microg
Clone:	AK-7
Gene:	3673
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?2.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Isotype:	Mouse IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	alpha2 integrin, VLA-2 alpha chain, Integrin alpha2