Purified anti-human CD49c (integrin alpha3)

Cat no: 343802

Supplier: BioLegend

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Description
Additional Information

CD49c is a 150 kD alpha integrin chain known as alpha3 integrin or VLA-3 alpha chain. It is a type I transmembrane glycoprotein which is proteolytically cleaved into two disulfide linked fragments of 125 kD and 30 kD. CD49c forms a heterodimer with integrin beta1 (alpha3beta1, CD49c/CD29, VLA-3) and is expressed by many types of adhesion cells, such as endothelial cells, epithelial cells, and dermal fibroblasts. Weak expression has been reported on leukocytes. VLA-3 plays a role in cell-cell and cell-matrix adhesion through binding Kalinin, collagen, laminin-1, laminin-5, entactin, and fibronectin.

Catalogue number:	343802
Reactivities:	Human
Hosts:	Mouse
Applications:	Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size:	100 microg
Clone:	ASC-1
Gene:	3675
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 1.0 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Human squamous cell carcinoma cell line SCC-9
Isotype:	Mouse IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	alpha3 integrin, integrin alpha3 chain, VLA-3 alpha chain, VLA3a, ITGA3