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Purified anti-human CLEC4A

Purified anti-human CLEC4A

Cat no: 355302

Supplier: BioLegend
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CLEC4A, also known as lectin-like immunoreceptor (LLIR) and dendritic cell immunoreceptor (DCIR), is a type II transmembrane protein belonging to C-type lectin domain family, and was previously designated as CLECSF6. It contains one carbohydrate recognition domain in its C-terminal extracellular domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain. CLEC4A is mainly expressed on monocytes, macrophages, dendritic cells, neutrophils, and B cells. It is also found on the surface of CD4+ T cells in rheumatoid arthritis (RA) patients. CLEC4A has been reported to function as a receptor for HIV, cross-present and cross-prime human CD8+ T cells. It might also function as a negative player by recruiting the SHP-1 or/and SHP-2 phosphotase through its immunoreceptor tyrosine-based inhibitory motif (ITIM).
Catalogue number: 355302
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100 microg
Clone: 9E8
Gene: 50856
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Ectodomain of CLEC4A-human Fc fusion protein
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: DCIR, LLIR, CLECSF6
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