Purified anti-human IL-16

Cat no: 519102

Supplier: BioLegend

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Description
Additional Information

Interleukin-16 is a proinflammatory cytokine synthesized as a 68 kD precursor molecule (pro-IL-16). After cleavage of pro-IL-16 by caspase-3, IL-16 is released as a 12 kD protein, but its biologic activities are exerted by a tetramer. IL-16 is a chemoattractant for CD4+ T cells, monocytes, and eosinophils. On T cells, IL-16 upregulates CD25 and class II expression, and also inhibits HIV-1 replication in vitro by repressing the transcription of the HIV-1 long terminal repeat. IL-16 is expressed by lymphocytes, macrophages, eosinophils, mast cells, epithelial cells, and fibroblasts. CD4 and CD9 are the receptors of IL-16.

Catalogue number:	519102
Reactivities:	Human
Hosts:	Mouse
Applications:	ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry
Size:	100 microg
Clone:	14.1
Gene:	3603
Dilutions:	Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.5 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Peptide corresponding to amino acids 615 to 630 (RRKSLQSKETTAAGDS) of IL-16
Isotype:	Mouse IgG2a
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Interleukin-16