Purified anti-human IL-18

IL-18, initially described as IFN-g inducing factor (IGIF), is a pro-inflammatory cytokine. It is an 18-kD cytokine which identified as a costimulatory factor for production of interferon-gamma (IFN-gamma) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24-kD molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. The cytokine IL-18 possesses pleiotropic biological properties such as activation of NF-kb, Fas ligand expression, induction of both CC and CXC chemokines, enhancement of the production of IFN-g and GM-CSF, and induction of CD4+ cytolytic T cell response. Its role in neurodegeneartion disease has also been reported.

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SPECIFICATIONS

Catalog Number

517302

Size

100 microg

Applications

WB

Hosts

Mouse

Reactivities

Hum

Clone

KU18-81

Antigen

Recombinant protein

Gene Id

3606

Isotype

Mouse IgM

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 4 microg/ml primary antibody concentration for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store undiluted at 4C.

Alternative Names

IL-1 gamma, IFN-gamma-inducing factor, IL1F4

Regulatory Status

RUO