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Purified anti-human IL-4

Purified anti-human IL-4

Cat no: 500702

Supplier: BioLegend
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IL-4 is a pleiotropic cytokine that is produced by activated T cells mast cells and basophils. IL-4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10 and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells. The 8D4-8 antibody can neutralize the bioactivity of natural or recombinant IL-4.
Catalogue number: 500702
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation
Size: 500 microg
Clone: 8D4-8
Gene: 3565
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The purified MP4-25D2 has been tested by blocking fluorochrome conjugated MP4-25D2 for intracellular cytokine staining. In order to obtain complete blocking results, a saturated amount of purified antibody (? 5.0 ug/million cells) should be used for incubation with target cells, prior to staining with fluorochrome conjugated antibody. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Yeast-expressed, recombinant human IL-4
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Interleukin-4, IaIF, BSF-1, HCGF, MCGF-2, MFF, TCGF-2
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