Home  >  Products  >  Purified anti-human Jagged 2
Purified anti-human Jagged 2

Purified anti-human Jagged 2

Cat no: 346902

Supplier: BioLegend
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
The binding of Notch ligands with their receptors results in the proteolysis of Notch and movement of intracellular portion of Notch into the nucleus. This translocation triggers a series of signaling process. The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate decision for various cell developments, including myogenesis, neurogenesis, and lymphocyte development. There is growing evidence that signals transmitted through different Notch ligands can differentially affect target cells. The Jagged-2 is one of the several Notch ligands identified. It is a single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL (Delta-Serrate-Lag-2) domain, followed by a tandem array of EGF-like repeats (ELRs) and cysteine-rich domain (CRD). Jagged 2 is expressed on lymphoma cells and some other tumor cells. Jagged-2 is reported to be essential for the regulation of spermatogenesis. Notch1/Jagged-2 signaling system plays an important role for male germ cells to differentiate, T cells and B cells to differentiate.
Catalogue number: 346902
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100 microg
Clone: MHJ2-523
Gene: 3714
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 2 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Human Jagged2-transfected CHO cells
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Jag2, Jagged-2
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave