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Purified anti-human LAP (TGF-beta1)

Purified anti-human LAP (TGF-beta1)

Cat no: 349602

Supplier: BioLegend
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TGF-beta1 (transforming growth factor beta1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many types of cells. Platelets express high level of TGF-beta. TGF-beta is synthesized as a large protein precursor and then secreted as a complex of TGF-beta and LAP (latency-associated peptide), in which LAP noncovalently associates with the dimeric mature TGF-beta to prevent its activity. TGF-beta requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-beta binds to the integrins alphavbeta1, alphavbeta6, alphavbeta8, and alpha8beta1 through RGD domain. TGF-beta plays important roles in control proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-beta is believed to be important in the regulation of the development of Treg, Th17, and Th9 cells. A recent study has shown that LAP is an activated Treg surface marker.
Catalogue number: 349602
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100 microg
Clone: TW4-2F8
Gene: 7040
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: LAP (TGF-beta)
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: TGFB, TGFB1, DPD1, Latency Associated Peptide (LAP), TGF-beta, TGF-B1
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