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Purified anti-human Lymphotoxin beta Receptor (LT-betaR)

Purified anti-human Lymphotoxin beta Receptor (LT-betaR)

Cat no: 322002

Supplier: BioLegend
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LT-betaR, also known as lymphotoxin beta receptor and tumor necrosis factor receptor superfamily member 3 is a 47 kD transmembrane protein containing 3 TNF receptor domains. The LT-betaR is a receptor for the heterotrimeric lymphotoxin complex (composed of LTalpha and LTbeta as well as LIGHT). LT-betaR is highly expressed in the lung, liver, and kidney and moderately expressed expressed in the heart and testes. LT-betaR is weakly expressed in the brain, thymus, spleen, and lymph nodes. The cytoplasmic tail of LT-betaR interacts with TRAF3, TRAF4, and TRAF5 as well as the hepatitis C virus core protein. Ligand binding to LT-betaR has been shown to induce apoptosis (via TRAF3 and TRAF5) and play a role in the development of lymphoid organs. The 31G4D8 antibody has been shown to be useful for flow cytometry, Western blot, immunoprepicitation and and ELISA (detection antibody). In addition, the 31G4D8 antibody is an agonistic antibody for the LT-betaR capable of inducing apoptosis (with IFN-gamma treatment).
Catalogue number: 322002
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunoprecipitation, Western Blot
Size: 100 microg
Clone: 31G4D8
Gene: 4055
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.5 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Human LT-betaR Fc protein
Isotype: Mouse IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Lymphotoxin b Receptor
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