Purified anti-human/mouse IL-21

Cat no: 514201

Supplier: BioLegend

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Description
Additional Information

Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.

Catalogue number:	514201
Reactivities:	Human, Mouse
Hosts:	Mouse
Applications:	Western Blot
Size:	50 microg
Clone:	5H3-O12-L23
Gene:	59067,60505
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 microg antibody per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	Upon receipt, store frozen at 4C.
Concentration:	0.5 mg/ml
Antigen:	Recombinant full length human IL-21
Isotype:	Mouse IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Interleukin 21