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Purified anti-human/mouse ZAP-70

Purified anti-human/mouse ZAP-70

Cat no: 313402

Supplier: BioLegend
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ZAP-70 is a 70 kD protein tyrosine kinase associated with the zeta chain of the T cell receptor. It is expressed in T cells and NK cells and has been shown to be involved in T cell signaling. Defects in ZAP-70 have been linked to selective T cell defects. The ZAP-70 kinase undergoes multiple phosphorylation events after T cell receptor engagement and interacts with a number of proteins involved in signal transduction. Recently, ZAP-70 has been identified as an important prognostic marker in B-cell chronic lymphocytic leukemia (B-CLL). The 1E7.2 monoclonal antibody recognizes human and mouse ZAP-70 and has been shown to be useful for flow cytometry, Western blotting, and immunoprecipitation.
Catalogue number: 313402
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
Size: 100 microg
Clone: 1E7.2
Gene: 22637,7353
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis or Western blotting. For immunofluorescent staining, the suggested use of this reagent is ? 0.5 microg per 106 cells in 100 microl volume. For Western blotting, the suggested working dilution(s)is 0.5-1 microg/ml. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: GST-fusion protein corresponding to residues 282-307 of human ZAP-70
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Zeta chain associated protein kinase, SYK related tyrosine kinase
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