Purified anti-human Tim-4

The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th-1 and Th-2) cell-mediated immunity. Tim-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of Tim-1. This binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and is connected to TIM-1-triggered Th2 responsiveness.

Prices direct from BioLegend

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

354002

Size

100 microg

Applications

FC

Hosts

Mouse

Reactivities

Hum

Clone

9F4

Antigen

Human TIM-4- IgV Fc, fusion protein

Gene Id

91937

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

SMUCKLER (Spleen, mucin-containg, knock-out of lymphotoxin (LT)), TIMD4, T-cell immunoglobulin and mucin domain containing 4

Regulatory Status

RUO