Purified anti-IkB-alpha

Cat no: 624902

Supplier: BioLegend

0 reviews | Write a Review Pencil

Description
Additional Information

IkappaB-alpha isan inhibitory protein that binds the NFkappaB complex and retains this complex in the cytoplasm where it cannot activate transcription. Upon cellular stimulation, the IkappaB proteins are phosphorylated and degraded via the ubiquitin pathway allowing nuclear translocation of NFkappaB. The NFkappaB complex binds DNA to activate gene expression of a number of a variety of proteins involved in inflammation, cellular proliferation, differentiation, and apoptosis. Poly6249 recognizes the C-terminal region of human, mouse, rat IKB-alpha and has been shown to be useful for Western blotting, immunoprecipitation, and immunohistochemistry.

Catalogue number:	624902
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunohistochemistry, Immunoprecipitation, Western Blot
Size:	200 microl
Clone:	Poly6249
Gene:	4792
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. For IHC, use a 1:50 dilution of antibody for staining. Antigen retrieval for IHC of formalin-fixed paraffin-embedded tissue using 0.01 M sodium citrate buffer is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C. DO NOT FREEZE.
Antigen:	Peptide mapping to the carboxy terminus of human IkappaB-alpha
Isotype:	Rabbit Polyclonal
Clonality:	Polyclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Nuclear factor of kappa light chain enhancer in B cells inhibitor alpha, IKBA

See Full Product Listings >

Purified anti-IkB-alpha

Cat no: 624902

About Biosave

Product Categories

Information